Produkty
Producenci
1-Alaninechlamydocin
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
1-Alaninechlamydocin is a cyclic tetrapeptide metabolite containing a single β-amino acid, which was isolated from a Tolypocladium sp. from the Great Lakes. It has anti-tumor activity due to the inhibition of histone deacetylase (HDAC).
1-Alaninechlamydocin is soluble in ethanol, methanol, DMF and DMSO.
Cas Number: 141446-96-0
Molecular Formula: C27H36N4O6
Molecular Weight: 512.6
Mechanism of Action: 1-Alaninechlamydocin exhibits potent antitumor activity and acts by inhibiting histone deacetylase.
Storage Conditions: -20°C
Purity Level: >95% by HPLC
Eukaryotic Cell Culture Applications:
1-Alaninechlamydocin reduces proliferation of MIA PaCa-2, PANC-1, and hTERT-HPNE cells (GI50s = 5.3, 14, and 2.0 nM, respectively).
Cancer Applications:
1-Alaninechlamydocin showed antiproliferative/cytotoxic activity in human pancreatic cancer cell line (MIA PaCa-2) at low-nanomolar concentrations. It also induced G2/M cell cycle arrest and apoptosis. Similar to other cyclic epoxytetrapeptides, its inhibitory effect is proposed to be via inhibition of HDAC activity (Du et al, 2014).
References:
Du L, Risinger AL, King JB, Powell DR and Cichewicz RH (2014) A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J. Nat. Prod. 77(7):1753-1757
Kim SD et al (1992) Han'guk Saenghwa Hakhoechi 25:5
Dane techniczne
| Opakowanie | 0.5 mg |