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5-Fluorouracil

nr kat.: F034-1G
Opakowanie: 1 g
Cena brutto: 233,70 zł 233.70
Cena netto: 190,00 zł
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Producent: TOKU-E
nr kat.: F034-1G

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

5-Fluorouracil is a synthetic growth inhibitor and a thymidylate synthase (TS) inhibitor.  It is named as there is a fluorine atom on the 5th carbon of a uracil ring.  Fluorouracil was patented in 1956 (Hoffman La-Roche).  Metabolites of 5-Fluorouracil use multiple targets to slow DNA and RNA processing and therefore cell growth. The compound can inhibit human cell growth induce apoptosis and is now used as an anti-cancer agent.  Derivatives of 5-Fluorouracil were isolated from the marine sponge Phakellia fusca, which is unusual since anti-cancer agents usually do not have analogs in nature.

5-Fluorouracil is sparingly soluble in water and slightly soluble in alcohol.

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

Cas Number: 51-21-8

Molecular Formula: C4H3FN2O2

Molecular Weight: 130.08

Mechanism of Action: In vivo 5-Fluorouracil is converted into active metabolites that target multiple parts of DNA and RNA synthesis including replacement of uracil and depletion of thymidine triphosphate (TTP).

Purity Level: >95% by HPLC

References: The spinosyn family of insecticides: realizing the potential of natural products research. Kirst H.A. J. Antibiot. 2010, 63, 101.

Neural network-based QSAR and insecticide discovery: spinetoram. Sparks T.C. et al. J. Comput. Aided Mol. Des. 2008, 22, 393.

DE-175 (spinetoram), a new semi-synthetic spinosyn in development. Crouse G.D. et al. in Modern Crop Protection Compounds Vol. 3 (eds Kramer W. & Schirmer U.) 2007, 1013.

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