Produkty
Producenci
7-Aminocephalosporanic Acid
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
7-Aminocephalosporanic Acid (7-ACA) is a key intermediate in the production of a wide variety of semisynthetic Cephalosporin antibiotics. It is an inhibitor of bacterial (S. aureus) β-lactamase. It is derived from mild acid hydrolysis of Cephalosporin C, catalyzed by GI-7-ACA acylase. Cephalosporin C was isolated in 1950 from Cephalosporium. 7-Aminocephalosporanic Acid can be used as a starting material to synthesize semi-synthetic cephalosporin antibiotics and their intermediates.
7-Aminocephalosporanic Acid is insoluble in water and DMSO.
Cas Number: 957-68-6
Molecular Formula: C10H12N2O5S
Molecular Weight: 272.28
Mechanism of Action: 7-Aminocephalosporanic Acid interferes with bacterial cell wall synthesis.
Storage Conditions: 2-8°C
Spectrum: Gram-positive bacteria
Form: Powder
References:
Bianchi D, Bortolo R, Golini P, and Cesti P et al (1998) Enzymatic transformation of Cephalosporin C to 7-ACA by simultaneous action of immobilized D-amino acid oxidase and glutaryl-7-ACA Acylase. Appl. Biochem. Biotechnol. 73: 257
Heugin AW, Cerny A, Zinkernagel RM, and Neftel KA (1986) Suppressive effects of B-lactam-antibiotics on in vitro generation of cytotoxic T-cells. Int. J. Immunopharmacol. 8(7):723-729
Loder B, Newton GGF, and E. P. Abraham EP (1961) The Cephalosporin C nucleus (7-Aminocephalosporanic Acid) and some of its derivatives. Biochem. J. 79(2):408-416 PMID 13763020
Morin RB, Jackson BG, Flynn EH and Roeske RW (1962) Chemistry of cephalosporin antibiotics. 1. 7-Aminocephalosporanic Acid from Cephalosporin C. J. Am. Chem. Soc. 84(17):3400-3401
Appearance: White or off-white powder
pH: 3.0 - 5.0
Loss on Drying: Not more than 1.0%
Absorbance: 425nm: Not more than 0.1
Optical Rotation: Not less than +86°
Solubility: Insoluble in water and DMSO
Sulfated Ash: Not more than 0.5%
Purity Level: Not less than 95.5%
Dane techniczne
| Opakowanie | 5 g |