Produkty
Producenci
A 54556A
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.
A 54556A is soluble in ethanol, methanol, DMF and DMSO.
Cas Number: 95398-45-1
Molecular Formula: C38H50N6O8
Molecular Weight: 718.8
Mechanism of Action: A 54556A acts by activating and dis-regulating Clp-family proteins.
Storage Conditions: -20°C
Purity Level: >95% by HPLC
References: A54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985.
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al. Nat. Struct. Molec. Biol. 2010, 17, 471.
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al. PNAS 2011, 108, 17474.
Dane techniczne
| Opakowanie | 1 mg |