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Amoxicillin Trihydrate

nr kat.: A004-25G
Opakowanie: 25 g
Cena brutto: 1 113,15 zł 1113.15
Cena netto: 905,00 zł
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Producent: TOKU-E
nr kat.: A004-25G

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

Amoxicillin is an extended spectrum ë_-lactam antibiotic similar in structure to Ampicillin. Resistance to Amoxicillin can be attributed to ë_-lactamase enzymes secreted by resistant cells.

TOKU-E offers three forms of Amoxicillin: 

Amoxicillin Trihydrate is effective against a variety of Gram-negative and Gram-positive bacteria.  The compound is slightly soluble in water.

Cas Number: 61336-70-7

Molecular Formula: C16H19N3O5S •3H2O

Molecular Weight: 419.45

Mechanism of Action: Like all β-lactams, amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.

Storage Conditions: 2-8°C

 Application

Spectrum: Amoxicillin targets a wide range of β-lactamase negative Gram positive and Gram negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Interestingly, amoxicillin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."

Microbiology Applications: Amoxicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

  • Neisseria gonorrhoeae 0.3 µg/mL - 32 µg/mL
  • Haemophilus influenzae 0.125 µg/mL - >64 µg/mL
  • For a complete list of Amoxicillin MIC values, click here.

Eukaryotic Cell Culture Applications: Dendritic cells were incubated with supernatant from Amoxicillin-treated hepatocytes to characterize drug-specific signaling pathways between hepatocytes and immune cells to study the influence of the compound on the immune response (Ogese, 2017).

 

Solubility: Benzene: Insoluble
Carbon tetrachloride: Insoluble
Chloroform: Insoluble
Methanol: Slightly soluble
Water: Slightly soluble

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