Amoxicillin Trihydrate
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Amoxicillin is an extended spectrum ë_-lactam antibiotic similar in structure to Ampicillin. Resistance to Amoxicillin can be attributed to ë_-lactamase enzymes secreted by resistant cells.
TOKU-E offers three forms of Amoxicillin:
- Amoxicillin Trihydrate (A004)
- Amoxicillin Sodium (A059)
- Amoxicillin : Potassium Clavulanate (2:1) (A054)
Amoxicillin Trihydrate is effective against a variety of Gram-negative and Gram-positive bacteria. The compound is slightly soluble in water.
Cas Number: 61336-70-7
Molecular Formula: C16H19N3O5S •3H2O
Molecular Weight: 419.45
Mechanism of Action: Like all β-lactams, amoxicillin targets PBP’s (penicillin binding proteins) involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised ultimately leading to the death of the cell.
Storage Conditions: 2-8°C
Application
Spectrum: Amoxicillin targets a wide range of β-lactamase negative Gram positive and Gram negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Interestingly, amoxicillin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."
Microbiology Applications: Amoxicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
- Neisseria gonorrhoeae 0.3 µg/mL - 32 µg/mL
- Haemophilus influenzae 0.125 µg/mL - >64 µg/mL
- For a complete list of Amoxicillin MIC values, click here.
Eukaryotic Cell Culture Applications: Dendritic cells were incubated with supernatant from Amoxicillin-treated hepatocytes to characterize drug-specific signaling pathways between hepatocytes and immune cells to study the influence of the compound on the immune response (Ogese, 2017).
Solubility: Benzene: Insoluble
Carbon tetrachloride: Insoluble
Chloroform: Insoluble
Methanol: Slightly soluble
Water: Slightly soluble
Dane techniczne
Opakowanie | 25 g |