Produkty
Producenci

Amphotericin B Solubilized

nr kat.: A008-500MG
Opakowanie: 500 mg
Cena brutto: 1 159,89 zł 1159.89
Cena netto: 943,00 zł
ilość szt.

towar niedostępny

dodaj do przechowalni
Producent: TOKU-E
nr kat.: A008-500MG

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

Amphotericin B, solublized is a solubilized form of the polyene antifungal or antimycotic, amphotericin B. Amphotericin B is a polyene antifungal or antimycotic compound derived from Streptomyces nodosus.

Standard powder amphotericin B is nearly insoluble in water and requires the addition of sodium deoxycholate to maximize solubility.

Mechanism of Action
Amphotericin B associates with membrane sterols in mammalian and fungal cell membranes. Amphotericin B forms a pore in these membranes leading to essential ion leakage and ultimately, cell death.

CAS Number: 1397-89-3 (Amphotericin B)

Molecular Formula: C47H73NO17 (Amphotericin B)

Molecular Weight: 924.08 (Amphotericin B)

Solubility: 0.05% in H2O: hazy yellow solution

Source: Streptomyces nodosus

Assay: (As Is): ≥240 µg/mg

Impurities
Mycoplasma: None detected

Endotoxin: ≤40 EU/mg

Spectrum
Amphotericin B is active against mammalian and fungal (molds and yeasts) cells. Amphotericin B is not toxic to bacteria due to their lack of sterols.

The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:
• Candida albicans - 0.001 - 321 μg/mL
• Candida krusei - 0.001 - 16 μg/mL
• Coccidioides immitis - 0.0625 - 2 μg/mL
• Cryptococcus neoformans - 0.2 - 39 μg/mL
• Fusarium oxysporum - 0.75 - 125 μg/mL

Microbiology Applications
Amphotericin B is used as an antimycotic selective agent in several routinely used selective media formulations to inhibit the growth of background fungal growth.

Eukaryotic Cell Culture Applications
Amphotericin B can be used in eukaryotic cell culture to control or prevent fungal contamination. Amphotericin B can be toxic to cell lines at high concentrations and should not be used at concentrations greater than 2.50 µg/mL.

References


  1. Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.
  2. Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.
  3. Brajtburg, J., W. G. Powderly, and G. Medoff. "Amphotericin B: Current Understanding of Mechanisms of Action." Antimicrobial Agents and Chemotherapy 34.2 (1990): 183-88. www.ncbi.gov. Web. 22 Aug. 2012.
  4. Perez-de-Luque A., Cifuentes Z., Beckstead J.A., Sillero J.C., Avila C., Rubio J. and Ryan R.O.. Effect of amphotericin B nanodisks on plant fungal diseases. Volume 68, Issue 1, Article first published online: 24 Jun 2011.

 

Dane techniczne

Opakowanie 500 mg

Produkty powiązane

do góry
Sklep jest w trybie podglądu
Pokaż pełną wersję strony
Sklep internetowy Shoper.pl