Produkty
Producenci
Anidulafungin
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Anidulafungin is a semi-synthetic echinocandin antifungal that is effective against Candida spp. Anidulafungin inhibits fungal cell wall synthesis. It is useful in pharmacotherapy and cell culture research applications.
Cas Number: 166663-25-8
Molecular Formula: C58H73N7O17
Molecular Weight: 1140.24
Mechanism of Action: Anidulafungin inhibits the enzyme (1→3)-β-D-glucan synthase, which is important in fungal cell wall synthesis.
Storage Conditions: -20°C
Spectrum: Anidulafungin is active against Candida and Aspergillus spp.
Eukaryotic Cell Culture Applications: Since the compound selectively targets fungal cells and does not exhibit cytotoxicity to mammalian cells in vitro (Harris and Coote, 2010), it is useful in cell culture to combat Candidaand Aspergillus spp.
Form: Powder
Appearance: White crystalline powder
Source: Semi-synthetic
Water Content (Karl Fischer): Not more than 2.0%
pH: 6.5 - 7.5
Heavy Metals: Not more than 5ppm
Identification: IR, HPLC - Passes test
Purity Level: HPLC - Not less than 98.0%
Impurity Profile: Impurities (HPLC): Not more than 2.0%
References:
Harris MR and Coote PJ (2010) Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro. Int. J. Antimicrob. Agents 35(4):347-356 PMID 20106636
Odds, FC, Brown AJ, Gow NA (2003) Antifungal Agents: Mechanisms of action. Trends Microbiol.11(6): 272-279 PMID 12823944
Pfaller, M A et al. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp, including 315 isolates resistant to fluconazole” J. Clinical Microbiol. 43(11):5425-5427
Salas V et al (2011) Anidulafungin in treatment of experimental invasive infection by : in vitro activity, (1-->3)-beta-D-glucan and mannan serum levels, histopathological findings, and in vivo efficacy. Antimicrob. Agents Chemother. 55 (11):4985-4989 PMID 21844324
Vazquez, JA and Sobel JD (2006) Anidulafungin: A novel echinocandin. Clin. Infect. Dis. 43(2):215-222 PMID 16779750
Dane techniczne
| Opakowanie | 10 mg |