Artesunate
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Artesunate is an anti-malarial drug and has been found to be effective against multidrug-resistant Plasmodium falciparum and P. vivax malaria. Artesunate has also been found to have anti-cancer activity against leukemia and colon cancer cell lines.
Cas Number: 88495-63-0
Molecular Formula: C19H28O8
Molecular Weight: 384.42
Mechanism of Action: Artesunate causes double stranded breaks in parasite DNA which leads to a buildup of intracellular reactive oxygen species (ROS).
Storage Conditions: ≤30°C
Spectrum: Artesunate is active against Plasmodium falciparum and P. vivax.
Form: Powder
Appearance: White crystalline powder
Source: Artemisia annua
pH: 3.5 - 5.0
Assay: (HPLC, On dried basis): 98.0% - 102.0%
Residue On Ignition: Not more than 0.1%
Heavy Metals: Not more than 20ppm
Loss on Drying: Not more than 0.5%
Melting Point: 132°C - 136°C
Optical Rotation: +4.5 - +6.5
Solubility: Slightly soluble in water, freely soluble in ethanol, acetone, and chloroform
Impurity Profile: Single impurity: Not more than 0.5%
Total impurities: Not more than 2.0%
Impurity Profile: Single impurity: Not more than 0.5%
Total impurities: Not more than 2.0%
References: Efferth, Thomas, Heather Dunstan, Axel Sauerbrey, Hayato Miyachi, and Christopher Chitambar. "The Anti-malarial Artesunate Is Also Active against Cancer." Int J Oncol International Journal of Oncology (2001): n. pag. Web.
Gopalakrishnan, Anusha M., and Nirbhay Kumar. "Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species." Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 59.1 (2014): 317-25. Web.
Dane techniczne
Opakowanie | 100 mg |