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Artesunate

nr kat.: A096-100MG
Opakowanie: 100 mg
Cena brutto: 611,31 zł 611.31
Cena netto: 497,00 zł
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Producent: TOKU-E
nr kat.: A096-100MG

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

Artesunate is an anti-malarial drug and has been found to be effective against multidrug-resistant Plasmodium falciparum and P. vivax malaria. Artesunate has also been found to have anti-cancer activity against leukemia and colon cancer cell lines.

Cas Number: 88495-63-0

Molecular Formula: C19H28O8

Molecular Weight: 384.42

Mechanism of Action: Artesunate causes double stranded breaks in parasite DNA which leads to a buildup of intracellular reactive oxygen species (ROS).

Storage Conditions: ≤30°C

Spectrum: Artesunate is active against Plasmodium falciparum and P. vivax.

Form: Powder

Appearance: White crystalline powder

Source: Artemisia annua  

pH: 3.5 - 5.0

Assay: (HPLC, On dried basis): 98.0% - 102.0%

Residue On Ignition: Not more than 0.1%

Heavy Metals: Not more than 20ppm

Loss on Drying: Not more than 0.5%

Melting Point: 132°C - 136°C

Optical Rotation: +4.5 - +6.5

Solubility: Slightly soluble in water, freely soluble in ethanol, acetone, and chloroform

Impurity Profile: Single impurity: Not more than 0.5%
Total impurities: Not more than 2.0%

Impurity Profile: Single impurity: Not more than 0.5%
                             Total impurities: Not more than 2.0%

References: Efferth, Thomas, Heather Dunstan, Axel Sauerbrey, Hayato Miyachi, and Christopher Chitambar. "The Anti-malarial Artesunate Is Also Active against Cancer." Int J Oncol International Journal of Oncology (2001): n. pag. Web.

Gopalakrishnan, Anusha M., and Nirbhay Kumar. "Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species." Antimicrobial Agents and Chemotherapy Antimicrob. Agents Chemother. 59.1 (2014): 317-25. Web.


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