Produkty
Producenci

Atovaquone

nr kat.: A099-10MG
Opakowanie: 10 mg
Cena brutto: 403,44 zł 403.44
Cena netto: 328,00 zł
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Producent: TOKU-E
nr kat.: A099-10MG

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

Atovaquone is a hydroxynaphthoquinone antimicrobial compound with antipneumocystic and anti-parasitic properties.

Cas Number: 95233-18-4

Molecular Formula: C22H19ClO3

Molecular Weight: 366.837

Mechanism of Action: Atovaquone inhibits cytochrome bc1 of the electron transport system leading to failure of mitochondrial function.

Storage Conditions: -20°C

Spectrum: Atovaquone is active against Plasmodium spp, Pneumocystis carinii, and Toxoplasma gondii in vivo and in vitro.

Form: Powder

Appearance: Yellow powder

Source: Synthetic

Water Content (Karl Fischer): Not more than 1.0%

Assay: (HPLC): 97.5% - 101.5%

Residue On Ignition: Not more than 0.1%

Heavy Metals: Not more than 10ppm

Solubility: Freely soluble in N-methyl-2-pyrolidone and in tetrahydrofuran; slightly soluble in ethyl acetate; insoluble in water

References: Looareesuwan, Sornchai, Jeffrey D. Chulay, Craig J. Canfield, and David B. Hutchinson. "MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE): A REVIEW OF ITS CLINICAL DEVELOPMENT FOR TREATMENT OF MALARIA." The American Society of Tropical Medicine and Hygiene 60.4 (1999): 533-41.

Nixon, G. L., D. M. Moss, A. E. Shone, D. G. Lalloo, N. Fisher, P. M. O'neill, S. A. Ward, and G. A. Biagini. "Antimalarial Pharmacology and Therapeutics of Atovaquone." Journal of Antimicrobial Chemotherapy68.5 (2013): 977-85.

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