Bleomycin A2 Sulfate, EvoPure™

nr kat.: B019-10MG

Opakowanie: 10 mg

Cena brutto: 3 630,96 zł 3630.96

Cena netto: 2 952,00 zł

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nr kat.: B019-10MG

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

Bleomycin A2 Sulfate, EvoPure® is a glycopeptide antibiotic used as a chemotherapeutic agent in the treatment of Hodgkin's lymphoma. Bleomycin A2 is structurally similar to the other compound found in Bleomycin (Bleomycin B2) and differs only by a terminal amine group.

We also offer:

Bleomycin A2 sulfate, EvoPure® (B019)
Bleomycin B2 sulfate, EvoPure® (B020)
Bleomycin sulfate (B005)
Demethylbleomycin A2 sulfate, EvoPure® (D023)

Cas Number: 11116-31-7 (Bleomycin A2 base)

Molecular Formula: C₅₅H₈₄N₁₇O₂₁S₃ · xH₂SO₄ (lot specific)

Molecular Weight: 1415.55 (Free base)

Mechanism of Action: The exact mechanism of action is not well defined; however, it is thought to chelate metallic ions to decrease enzyme activity and stability. This effect is believed to cause enzymes to react with oxygen producing free radicals which cause single-strand breaks in deoxyribose sugar.

Storage Conditions: -20°C

Plant Biology Applications: Bleomycin has been used in gene selection of tobacco, as only plants containing the Ble resistance gene were able to survive in the presence of Bleomycin (Miki et al, 2003).

Cancer Applications: Common treatment for Hodgkin's lymphoma.

Source: Streptomyces verticillus

pH: 4.5-6.0

Loss on Drying: ≤6.0%

Identification: IR, MS, NMR

Solubility: Water: 20 mg/mL

Purity Level: ≥96.0%

References:

Kole, C., Michler C.H., Abbott A.G. and Hall C.T. 2010. Transgenic Crop Plants: Volume 1: Principles and Development. Springer

Miki B., McHugh S., 2003 Selectable marker genes in transgenic plants: applications, alternatives and biosafety. Journal of Biotechnology 107 (2004) 193–232.

Dorr, R. T. "Bleomycin Pharmacology: Mechanism of Action and Resistance, and Clinical Pharmacokinetics." Seminars in Oncology 19.2 (1992): 3-8. Ncbi.gov. Web. 11 Sept. 2012.

"Monographs: Pharmaceutical Substances: Bleomycini Hydrochloridum - Bleomycin Hydrochloride." The International Pharmacopoeia. N.p., n.d. Web. 16 Jan. 2013.

Dane techniczne

Opakowanie

10 mg