Produkty
Producenci

THROMBIN from bovine

nr kat.: 0215416310
Opakowanie: 10 KU
Cena brutto: do wyceny
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Producent: MP Biomedicals
nr kat.: 0215416310

Opis

High purity grade, ≥1500 NIH u/mg protein

Applications
α-Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a hemostatic plug or a pathologic thrombus. In addition, thrombin potentiates the procoagulant process by activating Factors V, VIII, XI and XIII.

Product Description
Thrombin is prepared from fresh bovine plasma by an ion exchange method. Fibrinogen is removed from the prothrombin complex by precipitation. The concentrated prothrombin complex is then activated by beef thromboplastin and calcium. The thrombin solution is clarified by centrifugation and filtration and then lyophilized.

Biochem/physiol Actions
Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.

Unit Definition
The unit defined by the U.S. standard and is approximately equal to the stated unitage. A U.S. unit is defined as the amount required to clot 1 mL of standardized fibrinogen solution in 15 seconds. Approximately 2 U.S. units are required to clot 1 ml of oxalated human plasma in the same period of time. U.S units = NIH units.

Dane techniczne

Opakowanie 10 KU
do góry
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