Produkty
Producenci
Butyrolactone I
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
Butyrolactone I is soluble in ethanol, methanol, DMF and DMSO.
Cas Number: 87414-49-1
Molecular Formula: C24H24O7
Molecular Weight: 424.5
Mechanism of Action: Butyrolactone I inhibits the cell cycle at the G1/S and G2/M transitions.
Storage Conditions: -20°C
Purity Level: >95% by HPLC
References: Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta K. et al. Chem. Pharm. Bull. 1983, 31, 1528.
Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Suzuki M. et al. Cancer Lett. 1999, 138, 121.
Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Kitagawa M. et al. Oncogene 1993, 8, 2425.
Dane techniczne
| Opakowanie | 5 mg |