Produkty
Producenci
Aztreonam
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Aztreonam is a ë_-lactam antibiotic originally isolated from Chromobacterium violaceum. It is categorized as a monobactam as it contains a single ë_-lactam ring instead of the fused ë_-lactam and thiazolidine rings found in generic ë_-lactams. Due to its unique structure, Aztreonam is not typically inactivated by ë_-lactamases. Aztreonam is used to combat Gram-negative bacteria in microbiology, cancer therapy, and plant tissue culture. It is insoluble in water but is soluble in ethanol (20 mg/ml), DMSO (20 mg/ml) and DMF (30 mg/ml).
TOKU-E offers 2 forms of Aztreonam:
- Aztreonam (A017)
- Aztreonam, Solubilized (A038)
Cas Number: 78110-38-0
Molecular Formula: C13H17N5O8S2
Molecular Weight: 435.43
Mechanism of Action: β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
Storage Conditions: 2-8 °C
Application
Spectrum: Aztreonam is effective against Gram-negative bacteria.
Microbiology Applications: Aztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. Aztreonam has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
- Pseudomonas aeruginosa ≤0.12 µg/mL － >16 µg/mL
- Proteus mirabilis ≤0.12 µg/mL － >16 µg/mL
- For a complete list of aztreonam MIC values, click here.
Plant Biology Applications: Aztreonam is a broad-spectrum antibiotic commonly used in plant tissue culture to control bacterial contamination from Gram-negative species.
Cancer Applications: Aztreonam was effective as the single active antibiotic in the treatment of Gram-negative infections in neutropenic patients; however, it must be used in combination with another antibiotic to provide Gram-positive coverage.
Specification
Form: Powder
Appearance: White crystalline powder
Source: Synthetic
Water Content (Karl Fischer): ≤ 2.0%
Assay: (On Dried Basis): 94.0-103.0%
Residue On Ignition: ≤ 0.1%
Heavy Metals: ≤ 0.001%
Optical Rotation: -26° to -32°
Solubility: ethanol (20 mg/ml), DMSO (20 mg/ml) and DMF (30 mg/ml).
References:
Jones PG et al (1986) Aztreonam therapy in neutropenic patients with cancer. Am. J. Med. 81(2):243-248. PMID 3526885
Moreau-Marquis S, Coutemarsh B, Stanton BA (2015) Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate biofilms growing on cystic fibrosis airway epithelial cells. J. Antimicrob. Chemother 70(1):160-166. PMID 25213272
Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med. 1997; 103(1):51-59 PMID 9236486
Dane techniczne
| Opakowanie | 100 mg |