Produkty
Producenci
Bischloroanthrabenzoxocinone
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 µg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics.
Bischloroanthrabenzoxocinone is soluble in ethanol, methanol, DMF and DMSO.
Cas Number: 866022-28-8
Molecular Formula: C28H24O7Cl2
Molecular Weight: 542.1
Mechanism of Action: BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.
Storage Conditions: -20°C
Purity Level: >99% by HPLC
References: Determination of selectivity and efficacy of fatty acid synthesis inhibitors. Kodali S. et al. , J. Biol. Chem. 2005, 280, 1669.
Anthrabenzoxocinones from Streptomyces sp. as Liver X receptor ligands and antibacterial agents. Herath K. B. et al. , J. Nat. Prod. 2005, 68, 1437.
Dane techniczne
| Opakowanie | 0.5 mg |