Colistin Sulfate USP

nr kat.: C083-1G

Opakowanie: 1 g

Cena brutto: 1 061,49 zł 1061.49

Cena netto: 863,00 zł

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nr kat.: C083-1G

Opis

Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com

Colistin sulfate, USP (syn: polymyxin E) is a cationic, cyclic polypeptide antibiotic belonging to the polymyxin family. It is a natural product discovered in 1949 that is nonribosomally synthesized by Bacillus polymyxa subspecies colistinus Koyama. Colistin is mixture of Colistin A, B, and C. Colistin targets the bacterial cell membrane, leading to reduced permeability and cell death, and is effective against Gram-negative bacteria. It is soluble in water (50 mg/ml).

TOKU-E offers three forms of Colistin:

This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for details.

Cas Number: 1264-72-8

Molecular Formula: C₅₃H₁₀₀N₁₆O₁₃ • xH₂SO₄ (Colistin Sulfate A)

Molecular Weight: 1155.43 (Colistin Sulfate A)

Mechanism of Action: Colistin sulfate displaces essential ions (magnesium and calcium) in the lipopolysaccharide layer of the cell wall leading to local disturbance of the outer membrane, which causes increased permeability and eventually cell lysis. Colistin also has anti-endotoxin activity. The endotoxin of Gram-negative bacteria is the lipid A portion of the lipopolysaccharide molecules, and colistin binds and neutralizes the lipolysaccharide (Falagas et al, 2005).

Application

Spectrum: Colistin sulfate is used primarily against Gram-negative bacteria and can also be used against Mycobacteria.

Microbiology Applications: Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Colistin has also shown high potency against high-resistant superbug strains. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

Shigella spp. 64 µg/mL -128 µg/mL
Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL
For a complete list of colistin MIC values, click here.

Media Supplement

Colistin is routinely used as a selection agent in several types of isolation media:

Columbia Blood Agar - Campylobacter selective supplement (Butzler)

Columbia Blood Agar - Staphylococcus/Streptococcusselective supplement

Columbia Blood Agar - Streptococcus Selective Supplement

Listeria Selective Agar - Listeria Selective Supplement

Listeria Selective Agar - Modified Listeria Selective Supplement

Plant Biology Applications: Plasmodiophora brassicae spores were treated with colistin sulfate and used to inoculate hairy roots of cabbage, Chinese cabbage, turnip, and rape in a useful dual culture system for P. brassicae (Asano et al, 1999).

Solubility: 50mg/mL H₂O: Clear and Light yellow solution

Elemental Analysis: As≤2 ppm

Impurity Profile: Arsenic: ≤2ppm

Dane techniczne

Opakowanie

1 g