Lincomycin HCl EP

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Lincomycin HCl, EP is the hydrochloride form of Lincomycin, provided as the monohydrate.  Lincomycin is a naturally occurring lincosamide isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. This class of antibacterial contains a rare amino acid (4-propyl-N-methylprolin) coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin is often incorrectly considered an aminoglycoside but it actually shares little or no structural similarity.  It is effective for Gram-positive bacteria and disrupts protein synthesis.

Lincomycin is very soluble in water.  It is soluble in methanol and ethanol. 

Lincomycin HCl, EP conforms to European Pharmacopoeia specifications. 

We also offer:

• Lincomycin HCl, USP (L002)
• Lincomycin (L014)

Cas Number: 7179-49-9 (monohydrate); 859-18-7 (anhydrous)

Molecular Formula: C₁₈H₃₄N₂O₆S · HCl · H₂O

Molecular Weight: 461.02

Mechanism of Action: Lincosamide antibiotics inhibit bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to lincomycin is commonly attributed to mutations in 50S rRNA preventing lincomycin binding allowing the cell to synthesize proteins free of error.

Application

Spectrum: Lincomycin is a narrow-spectrum antibiotic effective against Gram-positive bacteria and protozoa. It is effective for Staphylococcus, Streptococcus, and Bacterioides. It has comparable activity to Erythromycin in vitro.

Microbiology Applications: Lincomycin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options.  Representative MIC values include:

• Staphylococcus aureus 0.2 µg/mL – 3.2 µg/mL
• Streptococcus pyogenes 0.04 µg/mL – 0.8 µg/mL
• For a complete list of lincomycin MIC values, click here.

Plant Biology Applications:

Lincomycin provides a powerful plant selection agent that facilitates recovery of plastid transformants.  Cultured Nicotiana cells were used in vitro.  Resistant cells are green versus sensitive cells are white on the selective medium.  Lincomycin is preferred over other antibiotics for chloroplast transformation because it also inhibits callus formation, greening, and subsequent shoot regeneration (Moll et al, 1990).

Specification