Vancomycin

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Vancomycin is a bactericidal glycopeptide antibiotic and has been used to treat infections caused by multi drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA).
Vancomycin is freely soluble in water. Click here for more vancomycin products.

Mechanism of Action
Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.

Spectrum
Vancomycin inhibits growth of many Gram positive bacteria including the antibiotic resistant superbug, MRSA (Methicillin resistant Staphylococcus aureus). Vancomcyin is effective for treating MRSA infections because it inhibits cell wall synthesis through a different mechanism than β-lactam antibiotics.

CAS Number: 1404-90-6

Molecular Formula: C₆₆H₇₅Cl₂N₉O₂₄

Molecular Weight: 1449.25

Purity Level: Vancomycin B: Not less than 93.0%

Impurity Profile
- Individual Impurity: Not more than 3.0%
- Related Substances: Not more than 7.0%
- Content of EDTA: Not more than 120 ppm 

Source: Streptomyces orientalis

Water Content (Karl Fisher): Not more than 20.0%

Absorbance: (465nm): Not more than 0.1

Assay
- (As Is): Not less than 850 µg/mg
- (Dried Basis): Not less than 950 µg/mg 
Residue On Ignition: Not more than 1.0%
Heavy Metals: Not more than 20 ppm

References

1. Courvalin, Patrice. "Vancomycin Resistance in Gram-Positive Cocci." Oxford Journals(2006): 25-34. Clinical Infectious Diseaes. Web. 21 Aug. 2012.
2. Pollock, H.M., Holt J., and Murray C., Comparison of susceptibilities of anaerobic bacteria to cefemenoxime, ceftriaxone and other antimicrobial compounds, Antimicrob. Agents Chemother., Vol. 23, pp.780-783, 1983
3. Silva J.A. and Fukai S., The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth, J. Appl. Hort., Vol. 3(1), pp. 3-12, 2001.
4. Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &...Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369