Produkty
Producenci
Borrelidin
Opis
Produkt przeznaczony wyłącznie do badań. Nie nadaje się do spożycia. Więcej informacji na stronie producenta www.toku-e.com
Borrelidin is an unusual nitrile-containing metabolite isolated from Streptomyces. Borrelidin is an important lead for antimalarial discovery, displaying activity against drug-resistant Plasmodia.
Borrelidin is soluble in ethanol, methanol, DMF and DMSO.
Cas Number: 7184-60-3
Molecular Formula: C28H43NO6
Molecular Weight: 489.6
Mechanism of Action: Borrelidin is a selective inhibitor of bacterial and eukaryal threonyl-tRNA synthetase and is a very potent angiogenesis inhibitor and induces apoptosis of the capillary tube-forming cells.
Storage Conditions: -20°C
Purity Level: >99% by HPLC
References: A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases. Ruan T. et al. , J. Biol. Chem. 2005, 280, 571.
Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. Wakabayashi T. et al. , J. Antibiot. 1997, 50, 671.
Anti-angiogenesis effects of borrelidin are mediated through distinct pathways: threonyl-tRNA synthetase and caspases are independently involved in suppression of proliferation and induction of apoptosis in endothelial cells. Kawamura T. et al. , J. Antibiot. 2003, 56, 709.
Dane techniczne
| Opakowanie | 0.5 mg |